"Whats a fish?"

when you're trying to get past the securitrons gaurding the strip gate, the failed science check "Robot, Let me pass!" always made me giggle.

Isn't thr success one pretty good too? I don't remember though.

Talking to Jessup:

Jessup : " What the hell? You're the courier Benny wasted back in Goodsprings. You're supposed to be dead! "

Courier: " I'm a ghost, here to haunt you. Oooooh... "

Best. Line. Ever.