I have about 50 mods(including obse plugins) and made sure to use boss to sort them out. I've already made sure they all work with each other heres my load order:
Oblivion.esm
ScreenEffects.esm
Oscuro's_Oblivion_Overhaul.esm
Kvatch Rebuilt.esm
CM Partners.esm
HorseCombatMaster.esm
Unofficial Oblivion Patch.esp
DLCShiveringIsles.esp
Unofficial Shivering Isles Patch.esp
Oblivion Vwalk UOS.esp
DLCShiveringIsles Vwalk UOS.esp
DLCShiveringIsles Vwalk DG_DS UOS.esp
NaturalWeather.esp
NaturalHabitat.esp
NaturalWater.esp
ClocksOfCyrodiilNoArcane.esp
Reznod_Mannequin.esp
Weapon Displays V1.9.esp
Living Economy.esp
Living Economy - Items.esp
Cutthroat Merchants.esp
Crowded Cities 30.esp
Crowded Roads 7.esp
Crowded Roads 7 Vwalk.esp
Crowded Cities 30 Vwalk.esp
Map Marker Overhaul.esp
DLCHorseArmor.esp
DLCHorseArmor - Unofficial Patch.esp
DLCOrrery.esp
DLCOrrery - Unofficial Patch.esp
DLCOrrery Vwalk.esp
DLCVileLair.esp
DLCVileLair - Unofficial Patch.esp
DLCMehrunesRazor.esp
DLCMehrunesRazor - Unofficial Patch.esp
DLCMehrunesRazor Vwalk UOP.esp
DLCSpellTomes.esp
DLCSpellTomes - Unofficial Patch.esp
ACCCGR SI.esp
ACCCGR.esp
Dragon Knight Armor v. 1.1.esp
SentientWeapon.esp
Dude Wheres My Horse.esp
DLCThievesDen.esp
DLCThievesDen - Unofficial Patch.esp
DLCThievesDen - Unofficial Patch - SSSB.esp
DLCThievesDen Vwalk UOP.esp
ExnemRuneskulls.esp
Oscuro's_Oblivion_Overhaul.esp
OOO-Water_Weeds.esp
OOO-No_Guild_Ownership.esp
OOO-Container_Trap_Instant_Effects.esp
Oscuro's_Oblivion_Overhaul Vwalk.esp
OOO-WaterFish.esp
KnightlyArmory.esp
Artefacts of the Ancestors.esp
BladeOfTheHaunted.esp
BladeOfTheHaunted Vwalk.esp
BladeSong.esp
BrotherhoodRenewed.esp
Abriael_Human.esp
GoldenCrest.esp
GoldenCrest Vwalk.esp
Housewives v101.esp
Kvatch Rebuilt.esp
Kvatch Rebuilt - OOO Compatibility.esp
Kvatch Rebuilt Vwalk.esp
OldCrowInn.esp
LostSwordOfTheAylied.esp
LostSwordOfTheAylied - Claymore Add-On.esp
LostSwordOfTheAylied - OBSE Add-On.esp
Malevolent.esp
Malevolent Vwalk.esp
eyja.esp
eyja Vwalk.esp
VHBloodlines 1.2.esp
VHBloodlines 1.2 Vwalk.esp
DLCBattlehornCastle.esp
DLCBattlehornCastle - Unofficial Patch.esp
DLCFrostcrag.esp
DLCFrostcrag - Unofficial Patch.esp
DLCFrostcrag Vwalk.esp
Knights.esp
Knights - Unofficial Patch.esp
Knights Vwalk UOP.esp
The Lost Spires.esp
The Lost Spires Vwalk.esp
Lost Paladins of the Divines.esp
HeartOftheDead.esp
mythsandlegends.esp
NaturalVegetation.esp
Harvest [Flora].esp
Harvest [Flora] - Shivering Isles.esp
Harvest [Flora] - DLCVileLair.esp
Harvest [Flora] - DLCFrostcrag.esp
Alternative Start by Robert Evrae.esp
LTDVampireOverhaul.esp
Circ Vamp Aesthetics.esp
SetEssentialActors.esp
Deadly Reflex 5 - Timed Block with no damage or durability changes.esp
DeadlyReflex 5 - Combat Moves.esp
Oblivion XP.esp
OOO-Level_Stock.esp
tkHairPack01.esp
Corean_hair_for_Original_race.esp
CuteElf11.esp
Beautiful People.esp
IDKRRR_C_race.esp
IDKRRR_C_race_closed_mouth_version.esp
Chocolate Elves.esp
CM Partners.esp
CM Partners Vwalk.esp
CM Partners NPC NE.esp
CM Partners NPC NE Vwalk.esp
CM Partners More NPCs NE.esp
CM Partners More NPCs NE Vwalk.esp
cmChocolates.esp
Companion_Ab_Human.esp
Companion_Ab_Human_2.esp
Companion_Ab_Human_3.esp
Companion_Ab_Human_4.esp
OOO-Respawn_Month.esp
ScreenControls.esp
LightSpellLiteBlue.esp
Soul Gem Creation.esp
cmKittyCole.esp
Aos Si.esp
treasurehunt.esp
Ren's hair on Young Hot NPCs.esp
Map Marker Overhaul - SI additions.esp

Keep in mind a few of theses mods aren't checked off in my OBMM and I also ran an Archive Invalidation.

Anyway problem is when I boot up oblivion and load a save it runs fine and loads fine. However once/if I die or even just decided to reload it crashes immediately. So I can load any save initially but once the game is started can't reload at all.