They have been stated in the GI article to be in this installment like it or not.
You get a perk every level (usually 1-50) but it is possible to get them all if you grind your levels enough I'm guessing. Much how the FO series have used perks.
Oblivion had a similar perk system where every quarter level(every 25 point) of a skill you recieve a small advantage.
http://www.uesp.net/wiki/Oblivion:Skill_Perks
Heres are the lists of perks from FO3 and FONV. Just to get an idea of what they are or how useful they can be and for ideas.
http://fallout.wikia.com/wiki/Fallout_3_perks
http://fallout.wikia.com/wiki/Fallout:_New_Vegas_perks
I'm not sure the level of how useful perks will be, until we actually see some examples.
-One stated by people who have read the GI article(I haven't read it yet) is a mace perk that goes through % damage through armor when using a mace/blunt weapon. Another stated was a perk that allows more dagger dmage during a successful stealth attack.
So any idea for perks?
Be creative, but try to be reasonable.