Sickly wastelander
This scruffy, sickly man cannot use any two-handed weapons or metal armor on account of his physical frailty. He survives mostly on his wits, but when that doesn't work, he's a very good shot with one-handed weapons such as revolvers, dart guns and sawed-off shotguns.
Tags: medicine, science, small guns.
Notable perks: educated, gunslinger, scrounger.
Stats: very low strength, endurance and charisma, very high int.
Looks: unkempt hair and beard.
Companions: dogmeat
Karma: neutral
Notes: partially inspired by the protagonist in the book/movie The Road.
Very fun character. Medicine helps counter his low HP and weak armor. He uses a scoped revolver for long range, and pistol or sawed-off shotty for close range. Dart gun is used on melee targets to cripple them. Even the .32 revolver saw some use on weaker targets when I needed to conserve 10mm ammo.
I'd like to come up with a fun character that uses energy weapons (which I never once took even in the old fallouts) but can't think of anything. I'm not very fond of those weapons because they're not very "wastelandish". Taking ideas.