I know this is not a unique problem but I wonder if there are by now any 'usual solutions'--the stuff I've found so far is quite old and consists of dozens of suggestions.

I'm playing on a new computer with an Nvidia 760 card, so I don't think my machine lacks any needed power. I have about 20 mods installed but most are small (e.g. Alluring Potion Bottles, Harvest Flora); the biggest are Francesco's, BT Mod, and Immersive Interface.

I used all these mods on my old machine and never had such a crash (although it often played very slowly, and some I did not install until after I was out of the starter dungeons). On the new machine the game played perfectly during the whole trek through the starter dungeon and sewers, but when I click on the final gate to get out, boom--CTD with an unenlightening error message.

At any rate, I'd welcome any suggestions as to what to do. I will try turning off a mod or two and see if that helps. I certainly hope I don't have to uninstall everything and start over with no guarantee of success. I'm not sure I have the determination for that.