Mass Effect was mentioned, and I have to say, I don't like the way that ME2 handled the whole 2-year gap. A few lines of dialogue at the beginning of the game, maybe one more when talking to the Virmire survivor, and that's it. Shepard has no real issues with having come back from the dead. There's got to be some sort of disconnect there; in fact, I imagine it would be worse for Shepard than for the Sole Survivor. The Sole Survivor comes back and almost everything is different. Oh, there's enough that's recognizable for it to throw him off every so often, but I imagine that life in the Wasteland is significantly different than life before the War, so it would be easier to adapt. For Shepard, on the other hand, it would be very different: while everything looks the same from a distance, if you get close and start examining the details, things come up differently. S/he hears about a movie coming out, but dies before s/he can see it. When s/he is revived, part 5 is now in theaters, with characters that were introduced in parts 2 and 4. But instead, Shepard simply plugs along, just fine with the fact that s/he's been dead for two years. Not only that, but let's go and recruit members of my former crew, undoing any emotional healing that might have occurred over the last two years.
Now, I do understand why the devs went that way. Having a main character who has to stop and put their head between their knees every so often because the universe is different than you remember doesn't make for interesting gaming. However, I don't think that the issue should be entirely ignored, either. Fallout 4, I think, has the opportunity to bring in the sort of response that a person might actually have in the Sole Survivor's situation without letting it completely sideline gameplay. Something like walking up to the baseball stadium, and having some sort of comment about how it's now a settlement instead of an entertainment center. Having dialogue options where you comment that you remember when the location that this store is used to be the dugout for the home team. Stuff like that. Oh, I realize that it's probably not going to happen, but it would be nice if it did.