Remember the standard rule of any RPG is to save alot and save often.
When the game start, one can config the control to that of the WASD players.
Also, if one is answering the questionnaire in the character making section, try to answer Ebony Dagger or Silver Staff if given the chance. These can hurt certain creatures, espeally the imp in the first dungeon. If not, one can just run past the imp instead.
When one get to town, try to to buy a Cart and/or Horse right away if ya have the money for it. Do not buy two of the same ie 2 Carts.
Take ya time on making ya toon to how one want.
One can punch a lock doors open if ya don't have an Open Spell or svck at Lockpicking.
Do not rest in town as that count as vagrancy and ya will be arrest. Grab an inn instead.
To use the weapon, just hold the "Swing Weapon" button and move ya mouse around.
There are time limits in quest, so be aware of that.
Anyways, good luck on ya first gameplay of Daggerfall.