All aboard the Irony train! Choo choo!

Doing the last CW quest? Kill Galmar/Rikke and use him/her to assist you in beating Ulfric/Tullius.

Safia is an old enemy of the Dark Brotherhood and understimates the Family? Turn her into your slave.

Wiping out the Silver Hand? Force Krev the Skinner to slaughter his/her former comrades.

And of course, the strong followers you can have thanks to its rather decent level cap.

Eh, I'm afraid that the closest I got was making those wolf trainers kill their own wolves. XD I haven't yet played a full-fledged necromancer though.

I've got one that I have to put a spoiler tag on because it involves a big name in the game.

Dead Thrall is great until a favorite Thrall dies, or the character You want to Thrall hits the Big 40