Often, when you trigger certain types of sounds, e.g. the "sipping water" sound or comments from nameless NPCs, the sound will be delayed (i.e. take a few seconds to play).
If you try to do anything during this delay, e.g. hit Esc or the a directional button, the game will freeze (no blue screen of death, just a visual freeze. The background music/radio keeps playing).
This happens to me a lot, though the game runs smoothly otherwise.
Computer stats:
4ghz quad-core AMD processor
On-board sound
1GB Nvidia graphics card
2 GB RAM