Destruction is kinda of the game's total crap skill for offense. Frankly I would consider alteration for the paraylisis effects and shields instead. Maybe conjuration for the bound weapons and summons over illusion too.
Conjuration is, without a doubt, the most OP magic skill in the game. However, alteration is of limited use to somebody already in heavy armour. The only spells which become useful eventually are dragonskin and the paralysis effect - whereas with illusion you have hands down the best crowd control in the game, and the ability to calm people/animals who attack you - which gives you time to regenerate. Not to mention invisibility and quiet casting.
Illusion is more a stealth skill - you use it so that you can get to places unseen, or eliminate whole armies without ever drawing your sword.