I have tried using Windows XP and Vista compatibility modes, turned off desktop composition, verified file integrity with Steam and nothing seems to remedy the problem. It seems to be graphic detail independent as I can put the graphics on super low and it will stop end up doing the same thing.
I'm on a Phenom II 555 and a GeForce GTX 260. Running with 3GB of system memory on Windows 7 x64.
Anyone have similar issues?