I use Psycho and Med-X regularly on my gimped characters to get that extra edge against harder enemies.
I use Buffout whenever I get overencumbered.
I use Mentats when I'm 13 points short of a speech check.
I use hydra for massive crippled limbs.
I use Turbo for Melee/Unarmed fighting deathclaws and cazadors.
Lots of uses for drugs IMO.
Alcohol I could do well without though.