No the ending is the same with the DLC's (battle at Hoover Dam) once you do that the game ends.
However there will be 4 (4 DLC's) locations where u can start the DLC in the Mojave. By entering those locations u can start the DLC. The other two DLC: Courier's stash and Gun Runner's Arsenal add equipment (mostly weaponry) to the game.
The four locations to enter the 4 DLC are in the far North (
Honest Hearts; http://fallout.wikia.com/wiki/Northern_Passage), South (
Old World Blues; http://fallout.wikia.com/wiki/Mojave_Drive-in), East (
Dead Money, http://fallout.wikia.com/wiki/Abandoned_Brotherhood_of_Steel_bunker), and West (
Lonesome Road; http://fallout.wikia.com/wiki/Canyon_wreckage).
You can only return to the Mojave at any time in the Lonesome Road DLC. The others require u to first finish the main quest before u can return to the Mojave. The only DLC you can not return to once finished is Dead Money.