Went to load my 60+ hour game yesterday (yes I'm addicted) and it froze up during load giving me 2 messages, the first being that the DLC was no longer available (must be referring to the "classic pack" that came with the game) and the second being that no storage device was selected when I tried to continue loading after the first message. Does anyone know what is going on with this by chance?

Look around these forums, especially the known bug list. Answers are there.

This is something that's been plaguing a LOT of the players lately, including me. I don't have quite as many hours logged as you, but I'm likely equally as pissed.

Try this, chances are a few of your save game are no longer working either. Try loading some of your games, some may work, some may not. One of mine still works but it's hours prior to encountering the problem.

Hopefully a patch comes out soon to address this issue, it's what most of us are waiting for.