1 handed guns:
Weathered 10mm pistol - Available from the beginning of the game, powerful and easier to use thand standard and can be modded. Not a holdout weapon like its counterpart.
Police Pistol - Strong base damage, bonus critical damage, easy to find ammo and easy to repair, and standard holdout weapon. Average spread for a pistol and standard crit rate.
.45 Auto Pistol - Strong damage, can be silenced and light weight. Large spread and ammo is bought or made only.
A Light Shining in Darkness - Powerful, good crit chance and lighter than any other handgun. Sightly above average spread and same ammo issue as above.
H&H Tools nail gun - Insane Rate of fire, always armor piercing and ammo is cheap to buy plus it can easily be made and it's capacity is incredible. Breaks downs fast (really fast).
5.56mm pistol - Improved holdout weapon compared to "That Gun" and has 6 different ammo types. Inferior to "That Gun" as a standard weapon.
Hunting Revolver(GRA) - Can be modded for decreased spread am an additional shot. Same stast as standard.
Sleepytyme - Improved holdout weapon, better all around compaired to the 10mm SMG. Expensive as heck to buy.
Li'l Devil - More powerful all around compaired to the 12.7mm pistol, great critical rage and slightly lighter too. Not a holdout weapon at any level of Sneak and the most expensive 1 handed gun in the game.
1 handed energy weapons:
Compliance Regulator- Long paralyzing effect, good critical chance, and easy to use and low spread. Poor damage.
Sonic emitter - Revelation- Paralysing effect, good use of ammo per shot. Pathetic range and slow rate of fire.
Sonic emitter - Gabriel's Bark - Powerful knockback effect, decent use of ammo. Pathetic range and slow rate of fire.
Sonic emitter - Opera Singer - bonus damage and limb bamage on crit, decent use of ammo. Pathetic range and slow rate of fire.
Sonic emitter - Tarantula - Ignites enemies on crit, and may autokill, stacks with pyromaniac, great use of ammo. Pathetic range and slow rate of fire.
Sonic emitter - Robo-Scorpion - Causes powerful explosion on crit, good use of ammo. Pathetic range and slow rate of fire, and can get caught in explosion easily.
Flare gun - Scares Abominations, Only 1 handed weapon to use Flamer Fuel. Poor durability, ammo usage and poor damage.
MF Hyperbreeder Alpha - Powerful and an insane rate of fire, no limit to ammo. Expensive.
Laser Pistol(GRA) - Can be modded for true iorn sights, extra damage and saving ammo. Same stats as standard.
Plasma Pistol(GRA) - Can be modded for increased damage, faster projectile speed and saving ammo. Same stats as standard.
Plasma Defender(GRA) - Cam be modded with a Scope, decreased spread and double the ammo. Same stats as Standard.
2 handed guns:
Automatic Rifle- Beastly DPS and DAM for an automatic weapon. Breaks down fast, expensive ammo and pathetically wide spread. (Power is everything option, basically)
.45 auto Submachinegun - Strong, and high rate of fire, sturdy for an automatic weapon. Ammo is an issue, and even modded, it has a wide spread.
Survivalist's rifle - Powerful, easy to repair, Small spread and great rate of fire. Expensive ammo.
Christine's COS silencer rifle- Powerful, high crit chance and easy to find ammo. Slower than standard, and breaks down quickly.
Sturdy caravan shotgun - Available from beginning of the game, powerful, easy on ammo and incredibly durable. Terrible spread.
Paciencia - Powerful, insane critical damage and easy to repair. only holds 3 shots and is expensive.
Medicine Stick - Powerful, extra ammo capacity. Expensive.
Bozar - Accurate for an automatic, low AP cost and common ammo. Reduced damage and clip size.
12.7mm SMG(GRA) - Can be modded for decreased spread, extra ammo and silencing. Same stats as standard.
Anti-materiel rifle(GRA) - Can be modded for reduced weight, reduced noise and increased rate of fire. Same stats as standard.
Assault carbine(GRA) - Can be modded for extra ammo, increased rate of fire and increased durability. Same stats as standard.
Battle Rifle - Cheap. All around inferior to "This Machine".
2 handed energy weapons.
Holorifle - Increadible power per cell, Decent DOT effect, sturdy, night scope, and can be modded to increas all effectiveness. Hard to repair.
LAER - Good damage per cell, conserves ammo with mods, decent crit chance. Fragile weapon, and expensive to repair.
Elijah's advanced LAER - Good damage per cell, conserves ammo with mods, decent crit chance and high rate of fire. Terribly brittle, and even more expensive to repair.
Tri-beam laser rifle(GRA) - Can be modded for increased damage, greatly increased condition, and double the ammo. Same stats as standard.
2 handed explosive weapons
Mercenary's grenade rifle - Available from the beginning of the game, Can be modded. Same stats as a standard Grenade Rifle.
Great Bear grenade rifle - Powerful, incredable durability. Have to nuke NCR to obtain it.
Red Victory grenade rifle - Light, great DPS. Have to Nuke Legion to get it.
25mm grenade APW - Semi-automatic with cheap and varied ammo, can be modded for increased capacity, increased projectile speed and increased rate of fire. Low crit chance and weaker per shot than standard grenade launchers.
This poll will continue, http://www.gamesas.com/index.php?/topic/1243841-dlc-weapons-pick-your-favouritescontinued/