Not really. Awop mucks about with many things. It mainly adds in a butt load of fairly well made dungeons. It also adds in weapons and armor drops. Which tends to be the main point of contention, even with the low loot version you can make a killing early on.
For npcs, I'd say awop is more concerned with adding in npc guards to protect towns from improved raiders. For example, the powder gangers in the starting quest might have some energy weapons and 50 cal sniper rifles. That can make things -- interesting if your running say project Nevada with it. I actually died several times before beating that encounter. Which was actually exciting.
Anyhow going from memory, as I uninstalled awop, I want a more vanilla game lately.