I've selected other cause the game suffers from one MAJOR flaw.
The treatment of SPECIAL as a set of additional perks means that character builds are no longer a necessity. For the first 20 or so levels your character is distinguished from another, but after that point you are free to spend points wherever you want, the result is a character without true limitations, and therefore a character without unique construct and value.
What makes it worse is the weird distribution of some perks. The hip-fire perk in Strength for example, or the Blitz perk in Agility, should have been in Perception/Strength respectively to allow more targeted character designs for ranged and melee respectively. It creates a system where you almost need to put points in stats you would have previously avoided to max out a certain skillset.
I know some people will disagree with me here, but I honestly think a lot of replay value is lost as a result of the novel SPECIAL system.
That being said there are essentially four factions you can complete the game with. None are uber-interesting, but interesting enough that you want to see where they end up, so essentially, or at least in my eyes, I will be re-rolling and replaying the game four times.
Comparatively Fallout 3 essentially had one faction and one ending stemming from that faction. Then again, I almost re-rolled immediately in FO3 cause the character designs felt distinguished.