Wish I could empathize OP, but I'm over 200 hours in and still have a metric ton of quests and locations to explore, not to mention doing things like finding my way up to all the accessible rooftops and elevated highways to see what's inter-connected where, that seem to be endless; and learning my way around the entire map, and particularly downtown, so it's second nature. After all that, then I'm going to concentrate on clearing, and building up settlements and properly outfitting the inhabitants...then, I'll start another play through with mods.
And I loved Skyrim, but I like FO4 more...probably has more to do with guns versus magic than anything though. Yeah, the whole ballistic weaponry and ammo thing could have been way better from a gun nut perspective (which I personally preferred the NV approach), but it's not a show stopper and modders will fix (rather...improve) that. If they had adopted and improved on that system and done things like lay off the magical Legendary weapon effects, this might have well been my perfect game.
But to each their own, I get it.