Just a thought, but have you tried disabling all of your mods and patches and maybe even starting a new game once they're disabled?
I haven't had this problem at all while running the Legendary Edition. I have mods, but I do not have the unofficial patches.
And if it works as it's supposed to once you disable everything, try enabling the patches/mods one at a time to find the culprit.
(Also, is it crashing a specific area?)