Anyone else having issues when playing that the pointer moves to the second monitor and clicks out of the game minimizing everything and subsequently killing you?

Capitan obvious would say just shut off the second monitor but it's not that difficult to code that in.

any ideas?

Not had that myself if your on Nvidia try setting "Multi-display / mixed-GPU Acceleration" to "Single Display Performance" in the Nvidia Control panel and see if that helps. Should also improve performance too.