You can just drop stuff on the ground, you know. The game only cleans out containers.
If you do that, I assume that this game can also suffer from the deletion effect.
Oblivion had it, and Fallout 3 had it. If you were to store an excessive amount of loot in one place, one of two things would happen. The first would be that if a certain threshold of items was reached, the games would start randomly deleting objects to cope with all the extra data taking up space in the area. I first noticed this in Oblivion, where I amassed an enormous collection of shiny, shiny jewels in a corner of my house, enough to make Uriel Septim wet his pants, only to come back a few game months later to find that the jewel pile had been reduced by about 90%. I did the jewel thing in Fallout 3, only that time, I used Pre-War money. The same thing happened in Fallout 3.
The second thing that could happen, and I bet you anything it can also happen in this game, is that some items would clip into other things, and fall through map geometry, eternally being lost in the dark voids of mapping hell.
These two things would weigh quite a bit of worry on me, if I choose to just drop my items on the ground.