It makes a difference. If, by some impossible chance, TES V was an MMO, I would complain on these forums as vocally as possible, screaming insults at ZeniMax and questioning their competency along the way. If ZeniMax online just released an MMO spin-off while I still got my single-player TES V from Bethesda Game Studios, I wouldn't have any problem whatsoever. Either way, however, I would not play an Elder Scrolls MMO. Paying monthly fees to play a game is something I would never do.
It's not a given that you have to pay monthly fees for a MMO, just look at Guildwars, Modern Warfare 2, Call of Duty Black Ops. It would svck to have to pay to play but still if, like the poll says, it was the most groundbreaking thing i've ever seen hell yes i would play it. If its a dinky piece of crap, no i wouldn't. It depends on the how much they have to sacrifice in game content for multiplayer.