I've created multiple "collector items" of the same kind and placed them in the Shivering Isles and Cyrodiil. Not multiple instances of one item, but multiple items that are similar. There is also a scroll with clues for where to find the items. But the items are initially disabled, so that you won't find them before you have the scroll.

My question is, would it be better to place a script on the scroll, that enables all the items when you add the scroll to your inventory, or is it better to place a script on the items, that enables them if you have the scroll?