Working our way backwards, I think ...
every game had such an event.
Give or take.
Oblivion. Champion, Mankar, Septims
Morrowind. Dagoth Ur, Nerevarine. Nerevar and his old Tribunal
Redguard. Cyrus. Richton
Battlespire. Mehrunes Dagon. The Hero/Apprentice. The Mentor
Daggerfall. Every party desires the Mantella, re-enacting the whole Talos/Undeking/Zurin bit.
Arena. Jagar Tharn, Uriel, The Champion
Then there was the actual Talos/Underking/Zurin bit. Wulfharth-Underking, a shadow of old Shor, gets his heart blown out (again). Talos plays the Dragon and uses the heart-mantella to reconstruct the Brass Divinity. History gets so warbled that soon, Tamriel (or us) believes all three are fused under one coin-personality. Or perhaps, since they were echoing the Romance of Akatosh and Lorkhan, the mythopoeia re-arranged the history, and not the other way around.
I may be reaching.
:>
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edit, re-reading this, there are so many wars and conflicts that I'm not quite sure what to pinpoint, whether certain parties resembled the Enantiomorph closely, whether the effects occurred on a grand scale, etc