while the main governing body of the enclave may have been purist (pure-human) dictators bent on eradicating anything that has been exposed to the new world, including any humans that live above ground, some members of the enclave seem ok. Arcade Gannon and his troops are in all regards just soldiers who followed there orders, while some do share the goals of the enclave, some cleary learned over time that it was wrong. So not all enclave remnants need be homicidal meglomaniacs. Even star wars has the empire, which is basicly a play on nazizsm, that later seems to reform to a less evil organization (according to some books that is) Same could happen with remnant enclave.
But still i doubt they will play a major role, as i think they would be too buisy getting their asses kicked by the lone wanderer at the time this game plays out