The courier- The Courier is simply, as the name implies, a delivery person hired by the Mojave Express, and was carrying a parcel with a platinum chip and some NCR war documents across the Mojave Wasteland to Primm. Left for dead and buried alive in a shallow grave with the assassin taking the parcel, the Courier is dug out by Victor, a friendly Securitron, and nursed back to health by Doctor Mitchell; doctor of the town of Goodsprings, who gives the Courier a 9mm pistol, a Vault 21 jumpsuit, and a Pip-Boy 3000.[1] The Courier will now have to find out who tried to kill him/her and what exactly was in the package he/she was carrying.
Mr House- House, a wealthy, powerful, germaphobe, who is based off http://en.wikipedia.org/wiki/Howard_Hughes
Benny- A thug who tried to kill you by shooting you in the head, he has a kickass pistol you might want to take.
Nightkin: Elite Super Mutants rewarded with the rare stealth boy, they are also blue schizophrenics
TV bot: common robot guard of Vegas, comes equipped with a missle launcher arm
Neil- disgruntled mutant in Tabithas army, If you pass a speech check, he can join you temporarily to take down tabitha
Doc Mitchell- Doctor in Goodsprings that ressurects the Courier, gives you an ink blob test
Victor- Doc Mitchell's bot, dug up the Courier. He's a Cowboy!
Easy Pete- an aged roughneck in Goodsprings, can supply the player with TNT
Tabitha- Crazed leader of the nation of State of Utolbitha
Sunny- a local ranger living in the town of Goodspring
Vulpes Inculta- a bald man and captain in Caeser Legion
Aaron Kimball-current president of NCR, he seems nice....
The great Khans- An incarnation of the Khan raider clan from fallout 1 and 2, in the all roads novel they were hired by benny to capture the courier
Raul- A Mexican ghoul said to be the Kif (from futurama) of New vegas
ED-E- An enclave eyebot who has a mission
Cassidy- The daughter of John Cassidy and just as fierce (and just as drunk)
Rex- A cyberdog, he really dosent like hats
Arcade Gannon- A doctor in the followers of the apocalypse
Deathclaws- They are recurring enemies throughout all of the fallout games, with tough skin and giant claws they can ruin any wastelanders day