One of the things I am loving so far is how much the enemy AI has improved and how varied the encounters are
Ghouls charge, robots overheat, deathclaws actually dodge your bullets
Raiders attack smartly. They take cover, they attack from different directions. Even if they don't know exactly where you are they react to your presence by firing in your rough direction etc
The enemy AI makes you think more about your approach than previous games and this time a mistake is as a result more highly punished