I'll make this as simple as possible, i'm sure many other people will have this same problem too.

Alot of times, enemies whether they be creatures or NPCs are running into my character from 10 seconds up to minutes without fighting my character. I have Oscuro's Oblivion Overhaul, does this glitch have anything to do with this Mod? What can i do to resolve this issue, so that i don't have to wait soo long for the enemies to stop running in to me and start fighting me?

Attacking them first doesn't seem to help, and sometimes it takes about half a minute up to a minute for the enemy to realise that i am around, to start getting ready to fight.

No slow hardware problems with my system ie. AMD 6850, Phenom 720 and 4gb.

Definitely sounds mod related. Never happened in my game

This.

Ask around on the mod forums, check for compatibility issues maybe.

If it is just to do with mods, then i have recieved enough adequate help, if there are no other possibilites then it makes it easier for me to resolve the issue myself thanks. At the moment the problem come and goes, but i havn't been experiencing it recently