I've got the perfect thing for a Fallout enemy: Mutated giant snakehead!
It's a fish... but it can travel on land!
And being mutated, it could pull it off with bloody results. Imagine: a wanderer travelling by the river is attacked by a giant, mutated fish. He escapes inland, thinking he's safe. But the fish doesn't think so: It simply slithers ashore and resumes it's assult with renewed vigor. A deatchlaw of the waters.
Here's the most ferocious picture I could find using a quick search, I am not sure if it's the exact species I mean, but gives the idea:
http://un2kmu.files.wordpress.com/2009/10/giant-snakehead-teeth.jpg (where the pictúre is from)
Of course, multiply it's size by about a hundred.