Be it knowing that a character is going to screw you over, or simply creating a dike of a character that kills everyone (even if it's family. If I interpret the baby generation and timeskip vault dweller right), sometimes you just want to kill a character, only to have them kneel down for a few seconds before getting back up.
Don't do that. At all.
With the characters that you really want alive, Have them run for their lives (only really aplicable if they're likely to get away. The dog might) Or have them get incapacitated (like, lying on the floor, not kneeling). Then the player has the option of finishing them off.
If you absolutely have to have a character essential, then have it
A- Really good at escaping on low health
B- knocked out completely, to come too in a few hours.
C- Generic and replaceable. Wipe the memory, Randomise the name, scramble the face, add a modifier to the voice so it sounds different.