I decided to today.
I've been playing my character as a Master Spy and Infiltrator carefully playing the Institute, Railroad, Minutemen (well not the Minutemen), and Brotherhood of Steel against one another with the intention of siding with the Railroad. Then I accidentally clicked on the Brotherhood of Steel mission to destroy the Railroad.
It would have been easy to reload.
But, the way it's framed, "Our forces are already there to eliminate them."
I can't help but think how FUNNY it would be in a story I was watching/reading to have the PC helpless to prevent his friends from being murdered by the BOS.
And the resulting consequences as he struggles to figure what to do NOW that his planned revolt is doomed.