I get the corrupt saves, too. My quicksaves are fine, but full saves are hit-or-miss for me. Testing various techniques as I go, viz how long I wait to shutdown my console after saving, how long I wait after saving before I exit and quit the game, how long I wait after performing my quicksave before I do the full save at the same spot. (Belt and suspenders, at this point.)
The only issue I have is that the Pipboy is broken. Not currently functioning at all. It makes the noises of it working but the screen is completely blank. It's driving me crazy. Absolutely bonkers. I haven't played FO4 in over a week. I spent far too much money on this game to not be able to play it. Uncool Bethesda. Completely uncool.