I'm thinking that Enclave could be explained through other things without having them in the actual game.
Like finding an old Enclave bunker with a bunch of useful history that explains a part of them more indept.
Maybe finding a crashed vertibird with a broken holotape that has a small segment of data remaining intact which fills a plothole.
Et cetera.
There are several ways to explain Enclave without having them there in the flesh.
What about a faction built up of humans "and" ghouls?
Which doesn't fight a tyrant group which wants to see them in chains.
I think Ghouls, Super Mutants, Hillfolk, Lobotomites, Trogs and other FEV experiments need to integrated into the society more.
I would like to see an Enclave civil war, something like Autumnian Enclave vs President Eden, if he managed to transport his AI to a hidden bunker, maybe even with a dormant army of robots/cyborgs. I can see something like that happening in the Commonwealth and if the game takes place after FO3, let's just hope they keep the Enclave intact after that, as a permanent faction in said region. Still, I would prefer the game taking place before FO3, maybe even let us build up a new faction to be.
A human + ghoul faction would certainly be interesting, but only in a region where that's likely to happen. Like somewhere up north maybe even New York, though I already hated all the rubble blocking paths in FO3 (talk about not cleaning the place), and I think NYC would be even worse where it might work with 'em politically correct Yankee liberals there. I don't think folks over here would take kindly to ghouls though (unless their friends happen to become ghoulified, hurray for hypocrisy). Though I also think everybody will have doubts about ghouls working in the food industry.
What's that thing floating around in my soup
Oh, that's just my finger smoothskin
A society of humans that enslaves, segregates, and genocides ghouls. (not enclave lol)
So you would enslave them, only to segregate them before you kill them, right? Wouldn't it be easier to just shoot them on sight (or SOS)?