Marijuana. Long decried as evil, it was found to grow abundantly even across the wasteland. But the Commonwealth researched it and refined into both fuel and lubricating oil. The Institute, Rivet City, and the Lyons[s] Brotherhood of Steel faction perfected both an all-wheel drive truck and a 4wheeler powered by liquified marijuana, motor vehicles began to reappear. across the wasteland. Trade and learning flourished.

In 2288, Sarah Lyons lead her 'Pride' in a motorized expedition to Chicago. The Enclave faction there formed alliance with the Brotherhood of Steel. Plasma weaponry and completely transistorized electronics were traded for fuel and machinery. The Followers of the Apocalypse soon were spreading. this knowledge everywhere.

Elsewhere, the New California Republic released one million wild horses into the New Vegas wastle land in 2289. Blacksmiths, cowboys, tack workers and veterinarians were exempt from military service if they relocated for ten years into the New Vegas wasteland. Trade and learning there, too; began to flourish. Eventually, they , two were destined to meet.

LOL its not even Evil in our society. Way less harmful than the other drugs.

So from what I take its about the NCR and ECBOS meeting up? OP to see NCR reaching the ECBOS by 2288. Another is FoTa spreading knowlege everywhere (Which I assume you mean all of the U.S.A).