the Races could be Humans, Ghouls, (sees how they play a major roll in the games), Super Mutants (play fall out 2 and you'll under stand why), the basic character configurations whould be from Fall out 3 as well as the armor, weapons, ammo, and items. as fro regeneration and lockpicking can still be used in missions and tresting up if no stimpacks are avail.
these are jsut some things that can make the game happen.