You need to be more specific. What does not work and how do you mean "does not work"?
The games are most accessible when you tag and develope at least small guns and speech (the third one could be anything really); bumb intelligence and agility as they are the most powerful stats; perks are pretty selfexplanatory (aim for
sniper,
more criticals, and
better criticals; and speech related perks). Save often, pay attention to what is happening and what NPC's tell you, tread carefully, and don't despair at failure because sometimes that just happens. You'll get the hang of it.