I think it would work (at least for me). I don't think it will happen. Part of Nintendo's (very successful) business strategy appears to be avoiding head-to-head competition with the PC/Xbox/PS3 crowd. Nintendo focuses on innovation and gameplay, while the others focus on adding more video RAM and copying Nintendo's more successful creations (Kinect, anyone?). Nintendo could add some fun aspects to Fallout gameplay with the new Wii U console, but the audience for Fallout would probably just moan about how it looks better on the PS4/Xbox820/whatever.
Nintendo didn't engage in direct competition with the other platforms of this generation because they were marketing towards a different demographic to the others. But it is a fair point that Nintendo consoles in general don't often have muti-platform games (except shovelware with the PS2 but I tend to block stuff like that from my memory). However, the Wii U seems to be bucking this trend with Batman: Arkham City (which I'm super-duper excited about) and a Battlefield game (was that actually confirmed?). All-in-all I think it's uncertain, but unlikely that Fallout will come to the Wii U and the lack of knowlege and support in this topic shows why. The "hardcoe" gamer hasn't kept up-to-date on Nintendo. There is little cross-over in fans of the Fallout series and fans of current/next-gen Nintendo.