Hi everyone. I made an account just to post here, as I've started having CTD problems as well. I've been playing since launch, with over 50 hours of gameplay on my file, and I had absolutely no problems until I acquired several of the quests frequently mentioned in this topic, such as Dangerous Minds and Shadow of Steel and its follow-up quests.
The weird thing is, I haven't even been to Monsignor Plaza yet, and I'm getting CTDs seemingly at random. I crashed at Hubris Comics, then things were fine for several hours. Then I crashed near The Slog, rebooted the game, fast travelled to Sanctuary, and about 5 minutes later, I crashed while using the weapons workbench there. I'm really want to say it has something to do with the Brotherhood quests, because I had no crashes whatsoever prior to the Brotherhood showing up in force, and it really seems beyond coincidence that so many people are having issues with these same quests. I know next to nothing about the internal workings of the game, but could it possibly have something to do with the Brotherhood's increased interactions with the game world after Shadow of Steel? (in addition to the Monsignor Plaza issues)
I really wish I had something more to go on here, or more information to give, but I've had no error messages, no other performance issues, nothing. Just a black screen, then suddenly I'm on the desktop.