The plot is going to be similar to the show, the Lone Wanderer's mother Catherine will be the narrator, similar to Mary Alice Young (and both are characters that die very early), and the 4 "Housewives" will be Mother Maya, Millicent Wellington, Bessie Lynn, and Christie Young. There will be a prologue as well as 4 chapters relating to each characte individually. Now some things I add about them might not be true to the actual story in Fallout 3, but it'll be to make these characters have a bigger plot.
I hope people will like this idea, and hope it's not weird that I'm basing my fanfic off that show.
Edit: Actually now that I think about it, I think it would be more interesting to do it about "Desperate Husbands" of Fallout 3, and have James be the narrator.