So from everything I have seen so far it looks like the shooting mechanics have been overhauled by a ton. Im not saying thats a bad thing at all, but when I see clips of the gameplay it seems like all I see is nothing but shoot em' up gameplay. I also keep hearing about how crafting and modding have been improved upon... also good things IMO. I just still have yet to see any news about things like the speech skill. The only thing I have heard in this area was that if the player wishes you will be able to complete the game without killing a single person... that made me breathe a little easier. Not saying I want a pacifist playthrough but I simply hate when im forced to kill in every situation to resolve a conflict.
I just really hope they put as much time into other aspects of Fallout as it seems they did with the action parts of the game. And honestly, seeing the few clips where the player has dialoge but only has four options to pick from makes me weary.