I don't understand how someone may survive FWE in accordance to these rules. FWE is hardcoe mode. But the TC implies that vanilla is the standard and I will stick my answer to it.
* Make the decision to pony up to your karma and choices early. If you are good then you are under it unless something extraordinary invalidates it. If you are a ghoul lover then you will protect them and found PETG.
* When you have are committed to hostility then you may only switch weapons if you are not in their sights ( behind safe cover ) unless it is to switch to and from grenades.
* VATS is allowed only for the initial sneak shot or sniping if you are the one who initiates ranged combat and have not been spotted yet. Use all your action points for that round and none thereafter.
* If, sitting in your chair you feel you must pee but your character is in battle then you must suffer through it until it is safe again. If you pee yourself then you may not take a shower until you find water.
* No jumping off of high places that would cripple, paralyze, or end your life had you jumped from such a height in the practical world of real life, where injury is painful and lasting and death is permanent.
* When a hostile manages to surprise or ambush you, don't be so eager to quickload. Play it out and when it is done you may reflect on whether or not you can life with the aftermath.