I can't believe hardly anyone has seen this interview that was done by, Eurogamer back in august of 2010 a few months before Skyrim was announced todd was telling the interviewer that him and co, where designing two games one being skyrim and the other obviously being Fallout 4 so that could give us a late 2012 release date at the earliest or a late/octoberish release date for 2013 which i think is most likely for Fallout 4 heres some excerts and i also have my bets that 4 is going to be primarlily in the Commonwealth/Boston its obvious at this stage.
"I spend a lot of my time on the game that's in pre-production, but the new game that's percolating takes the most of my time
Asked to confirm that he meant he was working on a second unannounced game, he said: "Right, so we're in production on the new game, and we have a design going for the one after that.
http://www.eurogamer.net/articles/2010-08-16-todd-howard-working-on-two-new-games