having some emptiness is good, not to mention that random encounters could turn those seemingly empty spaces into hot spots of interest.
one thing I disliked about FO3 was the tendacy for different hostile zones to overlap. walk slightly to the left and you run into a church with roaming super mutants, walk slightly to the right and you have a raider camp, try a different direction you have. I can understand why the developers didn't want there to be too many areas where you could by happenstance wander with out encountering any sort of threat to keep the game from seeming lifeless. but the overlapping was too agressive in that case. I feel that more space between locations and roaming hostiles needs to be a thing.