Another thing as well, you should be able to dismember a leg or something from your enemy without having them die. Lets say you take a missle launcher to a guys leg, blow off a leg, he goes sky high but when he lands he is barely alive. At that point you should be able to choose weather or not to help him out, let him sit there, or finish him off. Enemies should also be dynamically aware of when there too outgunned to fight, and at that point could surrender to the play and/or any faction that outnumbers them. Like a group of raiders surrendering to a Enclave squad.
Another thing that should be done is that you should not only be allowed way more than one follower, but you should be able to use tactics with them, like using the dpad to coordinated an ambush on a patrolling raider squad or talcon company squad or whoever. Could make combat much more fun and intresting, espcailly if the enemies set up the same thing for you an your followers. Like lets say you go wondering into a destroyed town, and it seems like its deserted. Then out of nowhere, 10 or so raiders pop out and start firing on you and your followers.
Also, dont have raiders always attack on sight. There should be some kind of faction rating system which can determine what factions are neutral, hostile, or friendly towards you. At this same time, you should be allowed to start you own "faction" as well. Like taking over a gang of raiders and controling what happens day to day. Or taking your followers and starting a talcon company-like faction where you can accept contracts for everything and anything that you feel like.
SPECAIL and STATS- Please make these matter more, in all honesty. Make it so you should need at least a strength of 6 to use a certain big gun, or a certain armor type. Make it so your endurance effects how much damage your limbs can take before thier crippled. Have it so you need a perception of like 7 or 8 inorder to use a sniper rifle. Make them matter in ways like that, so that if you reduce all of your things toa low number, you cant really use anything in the game, this will force character speacilization. Also make it so that what your SPECAIL stats are determines how many skill points a skill needs to go up.
As for skills, we need more. Small guns can be split into Pistols and Rifles and Automatic Weapons. Science can be split into robotics and computers. Sneak can be split into sneaking and pickpocketing. The trap skill should be brought back for setting up complex and elaborate traps. Medicine should be split into healing and rad healing. There is alot of room for upgrading the skills system here. While im on it, bring back the fallout 2 perk system, we dont need perks at every level you know.
And i must say, please allow us to upgrade our current weapons. Like being able to use a camera or microscope to make a scope for our hunting rifles. And give us a bigger variety of weapons too. There were some in fo3, but theres always room for more.
thats my 2cents.