My gut feeling and this is predictions/speculation but I'm thinking
this will take place after FO3 and new vegas in the year 2299. Takes place in Commonwealth, (1st expansion New York City maybe wink wink)
The Geck from Fallout 3 will be important and help colonize stuff but not completely
Lyons BOS expanded northward, might be other BOS groups from west or some that split off from lyons originally after the Pitt. They will have an argument over some tech in the institute
You awake in Vault 111 and don't remember anything, you then leave to find your memory, find yourself in the middle of a turf war and that's it for right now with the limited info we have.
Deathclaws will be inspired by New Vegas (We need Todd's opinion on that game) and will be deadly early on in the game.
Charisma is still going to be useless, I can dream it will actually be good.