For my fellow cynics, let's play a game.
Plausible nightmare scenarios for Fallout 4 that would just make me facepalm and cry:
-Cazadors are in Boston "becuz kewl"
-Turbo is in Boston "becuz awsum"
-Nightstalkers are in Boston "becuz iunno why not *blatant ignorance of lore*"
-The plot is basically about "R ANDROIDS AS REAL AS U OR ME OR SHULD WE USE DEM AS MINDLESS SLAVES CUZ DEY JUS ROBOTS???"
-Everything got re-nuked somehow ("The Courier rerouted the Divide missles to hit Boston cause the Courier hates Boston!!11")
-It's a prequel AKA the lazy writer's favorite ace-in-the-hole for moving a story forward without actually making any progress at all (I.E. just after the Great War, though the 2299 number may silence this possibility)
-Three Dog and other fan-service cameos occur not because they're actually plausible or make sense, but because FAN SERVICE!!
-Bethesda hires one singular big-name voice actor and kills him off almost immediately, the rest of the voice cast is mediocre or poor
-We fight aliens with the assistance of Optimus-I mean Liberty Prime
-The plot in some way fails to truly understand the meaning behind "War Never Changes" and instead has a very simplistic good-vs-evil outline where one side is completely justified for waging war and the other might as well be guys with curly moustaches tying dames to railroad tracks
-The Enclave are back
-For some reason, many of the perks, SPECIAL effects, Traits and other such features introduced in Fallout New Vegas are simply -not- included with no explanation as to why whatsoever. Meanwhile, some of the more broken overpowered perks like "Almost Perfect," Implant GRX and the three end-game perks from New Vegas still make the cut
-There's a magical "omg 100 damage a shot x5 crit multiplier assault rifle" that trumps every other weapon
-Damage resistance, not damage threshold, is still the standard defense stat and yes hitting the cap is more than doable
-Enemies continue to gain HP exponentially while their damage is either too pathetic or practically oneshots anyone
-SPECIAL is cut