1. I agree that it would be a lot of work to have SM dialogue choices and reactions from NPC's, though not impossible.
2. I would just hope if FEV was implemented (not saying I want it) It would be handled well from a writing perspective.
1.
Oh yeah definitely, it could work, but with Bethesda?
2.
I don't think it can work in any way. FEV has been used in three games now, rehashing old ideas is never good.
I had an idea for a mutated race. The US was experiementing with more things than just FEV, another thing was gene-splicing and trying to adapt humans to certain creatures DNA structures for super soldiers of other kinds.
Prisoners sentenced to death were sent to this place in Canada where they experiemented on them with the idea of mutating them with lizards so that if successful, a soldier could regenerate an entire arm!
Thing is, the great war broke out.
The prisoners escaped, and these were not good men at all, and they forcefully fornicated women and reaked havoc.
The prisoners themselves never mutated that much, the mutation laid dormant, passive in their gene structure.
The women who got impregnated by them on the other hand? They gave birth to something.
The Lacerta's/Snake Eyes.
If written right then we can have new things without having to resort to FEV over and over.
Cause come on. Fallout has to evolve beyond what it first was in it's fictional world.
We can't have Enclave, BOS and Super Mutants all the time.
All three need to go at some point and make way for new things so that Fallout can move forward, not stagnate.
So personally, I see no way FEV could be used again and it being acceptable. Bethesda wasted that chance with Vault 87.
[edit]
Now if FEV was used as merely a side-thing it could be used though.
Like my Lacerta/Snake Eye mutation, one of the ingredients for this successful mutation could have been trace amounts of FEV, whether it was the airbourne or clean FEV sent to the lab can remain a mystery.
But it could be used in addition to other things to help out with mutations.
But pure FEV? Hell, even contaminated FEV is a strict no-no in my book. Been there, done that. Time for new things and for Super Mutants to die out unless they find a cure for their sterility.