I think there should be more than one way to getting into somewhere that's otherwise locked. Either doing the classic lock pick gig which requires the typical lock pick skill, or if you have the strength to do it, kick the door in. Or if you're explosives capable, simply blow it up with the risk of something or other.
Si.
Lockpick for the stealthy and most risk-free way to open a lock.
Steal for stealing keys from NPC's that own said lock, but with a chance to be caught if failed stealing the keys.
Explosives for completely demolishing the lock and door, this will alert any hostile NPC's as well as allied NPC's, if caught by allies then you lose rep and they might go hostile.
Strength for destroying the lock through brute force, it does the same as explosives but on a smaller area.
And Science/Chemistry for crafting an acid to burn through the lock, if said skill is too low then you might mess up the lock and jam the door completely. Acids can be used until it works, explosives and brute force can also be used on a jammed lock.
"Doesn't this make Lockpick useless?"
Nope, Lockpick is still useful cause it's silent and won't alert others.
Acids are expensive and hard to craft.
Strength and explosives are loud and will alert enemies and allies, neither of which will be happy to see what you've done.
And Stealing keys only work with NPC's that has keys for said locks.