Not really, I mean the general theme is there but I think the setting, characters, and tons of side quests will set them apart. Besides, I'm not sure what the last video game I played was that had a truly original story, and I'll at least give Bethesda the benefit of the doubt. Just hoping it's less black-and-white than "noble Railroad of freedom vs. evil slaving Institute"
On a side note, I enjoyed the new trailer and I'm pretty buzzed about The Day being less than a week away.
Fun fact: I read somewhere about what the original plot twist to Mass Effect was going to be: the relays obviously manipulate spacetime to function, but the side effects linger. Basically, the more species advance scientifically, the more the can use the relays, and the faster spacetime degrades, which will cause gravitational anomalies to slowly destroy the universe. This is still hinted as a reason the Quarians' sun is failing. The Reapers kill civilization to stop spacetime degrading, saving the universe. They still allow a certain time for civilization to flourish, I guess based on their calculations of how much the relay use impacts spacetime. Really makes the Reapers more sympathetic, especially since they make a point of saving the genetic material of species they exterminate. So the choice wouldn't end up being synth vs. human, it would be "sacrifice ourselves to give other civilizations a chance in the future" vs. "pull out all the stops, doom the universe but enjoy it while it lasts." I'm not sure if this was an official story at one point or if I made that up, but it makes you think.