thread 1: http://www.gamesas.com/topic/1523978-fallout-4-timeline
Continuation of previous thread.
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EDIT: additional information added below.
Looking at the information from the original thread, I suggested a number of reasons why I believe that Fallout 4 will start in 2285. One additional reason for this would be the inclusion of certain characters from previous games in the series, especially those seen in Fallout 3.
I have already suggested Arthur Maxson, and have demonstrated fairly strong evidence to support this, although we are still only speculating at this stage.
But there are other characters of particular interest, the most prominent of which, in my opinion, are Bryan Wilks, and the residents of Little Lamplight.
Bryan Wilks managed to survive completely on his own after the attack on Grayditch, in spite of being only 8 years old at the time. After we complete the side quest "Those", we are given opportunity to send him to Rivet City to live with his aunt, Vera Weatherly. If this option is considered canon (which is more than likely), then Bryan and Vera could potentially have later relocated to the Commonwealth in order to make a 'fresh start'. Bryan may then perhaps be able to offer us a new side quest or two.
As for Little Lamplight, we have a whole host of options open to us that would be interesting if brought into Fallout 4. One particular point, similar to the case of both Wilks and Maxson, is their age. Being that all of the residents of Little Lamplight were below 16 in Fallout 3, if some of them were perhaps also to relocate to the Commonwealth, they would be aged between 17 and 23. For example, at 19, Lucy could be practising as a doctor somewhere in Diamond City, or we could even find a 22 year-old Knick Knack running a weapon shop in Scollay Square (after all, he did have a schematic for the Bottlecap Mine). Note that Lucy actually had knowledge regarding the "Replicated Man", and so her turning up in the Commonwealth would be quite fitting, as well as more than a little 'mysterious'.
EDIT: just to clarify, I am talking about a handful of individuals from Fallout 3 possibly showing up in the Commonwealth, not an entire community relocating. Also, this could be any combination of advlt or child NPCs.